In the 2023 Annual EconPol Europe Conference, we discuss future challenges for the EU such as the need for a technological and green transformation, dependencies from autocratic states, supply chain resilience, energy crisis, and the risks associated with protectionism and the creation of regional blocs. We will draw lessons from the current energy crisis and discuss the role of the EU, implications for fiscal and economic policy, and the power of the EU single market to overcome these challenges and ensure a prosperous and sustainable Europe.